Synechocystis sp. PCC6803

Synechocystis sp. PCC6803 is a cyanobacterium considered as a candidate photo-biological production platform an attractive cell factory capable of using CO2 and light as carbon and energy source, respectively. Compilation and characterization of Synechocystis genome-scale metabolic model is a pre-requisite towards achieving a proficient photosynthetic cell factory. To this end, we report two genome-scale metabolic models: iSyn669, which includes 882 reactions, associated with 669 genes, and 790 metabolites and iSyn811, an upgraded genome-scale metabolic model of this cyanobacteria consisting of 956 reactions and accounting for 811 genes and 911 metabolites. These models have been thoroughly studied with tools and algorithms such as flux balance analysis, knock-out analysis, gene essentiality, flux coupling analysis, reporter features and industrially-relevant metabolites production (hydrogen, succinate, ethanol). These models will greatly facilitate the development of cyanobacteria as green microbial cell factories(1)(2).


Synechocystis sp. PCC6803 model iSyn669
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Synechocystis sp. PCC6803 model iSyn811
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Instructions / manual:

1) A. Montagud, E. Navarro, P. Fernández de Córdoba, J. F. Urchueguía, K. R. Patil (2010) Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium BMC Systems Biology. 2010;4:156
2) A. Montagud, A. Zelezniak, E. Navarro, P. Fernández de Córdoba, J. F. Urchueguía, K. R. Patil (2011) Flux coupling and transcriptional regulation within metabolic network of photosynthetic bacterium Synechocystis sp. PCC6803 Biotechnology Journal 2011 Mar;6(3):330-42
A * indicates that these authors contributed equally to the work.