Ashbya gossypii

Ashybya gossypii, also known as Eremothecium gossypii is a filamentous fungi used widey for the production of Ribofavin and Vitamin B2. The model of this organism iRL766 is constructed using RAVEN, COBRA toolbox with the functionalities homology based and Hidden Markov Model (HMM) analysis and finaly curated manually. The model is validated by biomass growth, riboflavin production and substrate utilization predictions. The metabolic network constructed comprises 1596 unique metabolic reactions, 1349 metabolites in four sub-cellular compartments; extracellular, cytoplasmic, mitochondrial, and peroxisomal.


A.gossypii model iRL766

Instructions / manual:

1) Ledesma-Amaro R, Kerkhoven EJ, Revuelta JL, Nielsen J (2013) Genome scale metabolic modeling of the riboflavin overproducer Ashbya gossypii. Biotechnol Bioeng. doi: 10.1002/bit.25167.
A * indicates that these authors contributed equally to the work.